Amylin: pharmacology, physiology, and clinical potential

DL Hay, S Chen, TA Lutz, DG Parkes, JD Roth - Pharmacological reviews, 2015 - ASPET
Amylin is a pancreatic β-cell hormone that produces effects in several different organ
systems. Here, we review the literature in rodents and in humans on amylin research since …

Impact of GLP-1 receptor agonists on blood pressure, heart rate and hypertension among patients with type 2 diabetes: a systematic review and network meta …

F Sun, S Wu, S Guo, K Yu, Z Yang, L Li, Y Zhang… - Diabetes research and …, 2015 - Elsevier
Aims To evaluate current evidence of glucagon-like peptide-1 receptor agonists (GLP-1RAs)
on blood pressure, heart rate, and hypertension in patients with type 2 diabetes. Methods …

Effect of glucagon-like peptide-1 receptor agonists on lipid profiles among type 2 diabetes: a systematic review and network meta-analysis

F Sun, S Wu, J Wang, S Guo, S Chai, Z Yang, L Li… - Clinical …, 2015 - Elsevier
Purpose The goal of this study was to assess the effect of glucagon-like peptide-1 receptor
agonists (GLP-1 RAs) on lipid profiles in patients with type 2 diabetes. Methods The …

The place of dipeptidyl peptidase‐4 inhibitors in type 2 diabetes therapeutics: A “me too” or “the special one” antidiabetic class?

R Godinho, C Mega… - Journal of diabetes …, 2015 - Wiley Online Library
Incretin‐based therapies, the most recent therapeutic options for type 2 diabetes mellitus
(T2DM) management, can modify various elements of the disease, including hypersecretion …

Glucagon receptor blockade with a human antibody normalizes blood glucose in diabetic mice and monkeys

H Okamoto, J Kim, JP Aglione, J Lee, K Cavino… - …, 2015 - academic.oup.com
Antagonizing glucagon action represents an attractive therapeutic option for reducing
hepatic glucose production in settings of hyperglycemia where glucagon excess plays a key …

Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes

M Christensen, S Calanna, AH Sparre-Ulrich… - Diabetes, 2015 - Am Diabetes Assoc
Glucose-dependent insulinotropic polypeptide (GIP) is glucagonotropic, and glucagon-like
peptide-1 (GLP-1) is glucagonostatic. We studied the effects of GIP and GLP-1 on glucagon …

[HTML][HTML] Peptidyl hormones of endocrine cells origin in the gut—Their discovery and physiological relevance

P Ceranowicz, Z Warzecha, A Dembinski - J. Physiol. Pharmacol, 2015 - jpp.krakow.pl
In 1902 William Bayliss and Ernest Starling discovered secretin and it was the beginning of
general endocrinology as well as, endocrinology of gastrointestinal tract. Ernest Starling was …

Preservation of the blood brain barrier and cortical neuronal tissue by liraglutide, a long acting glucagon-like-1 analogue, after experimental traumatic brain injury

J Hakon, K Ruscher, B Romner, G Tomasevic - PLoS One, 2015 - journals.plos.org
Cerebral edema is a common complication following moderate and severe traumatic brain
injury (TBI), and a significant risk factor for development of neuronal death and deterioration …

Gastric bypass alters both glucose‐dependent and glucose‐independent regulation of islet hormone secretion

M Salehi, SC Woods, DA D'Alessio - Obesity, 2015 - Wiley Online Library
Objective Roux‐en‐Y gastric bypass surgery (GB) is characterized by accentuated but short‐
lived postprandial elevations of blood glucose and insulin. This profile has been attributed to …

Effect of GLP-1 receptor agonists on waist circumference among type 2 diabetes patients: a systematic review and network meta-analysis

F Sun, S Wu, S Guo, K Yu, Z Yang, L Li, Y Zhang, L Ji… - Endocrine, 2015 - Springer
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in patients
with type 2 diabetes. However, the effect on abdominal obesity has not yet been confirmed …