[HTML][HTML] Phagocytosis of apoptotic cells in homeostasis

S Arandjelovic, KS Ravichandran - Nature immunology, 2015 - nature.com
Human bodies collectively turn over about 200 billion to 300 billion cells every day. Such
turnover is an integral part of embryonic and postnatal development, as well as routine …

Regulation of macrophage development and function in peripheral tissues

Y Lavin, A Mortha, A Rahman, M Merad - Nature Reviews Immunology, 2015 - nature.com
Macrophages are immune cells of haematopoietic origin that provide crucial innate immune
defence and have tissue-specific functions in the regulation and maintenance of organ …

[HTML][HTML] GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+ MHCII+ macrophages and dendritic cells

J Helft, J Böttcher, P Chakravarty, S Zelenay, J Huotari… - Immunity, 2015 - cell.com
Dendritic cells (DCs) are key players in the immune system. Much of their biology has been
elucidated via culture systems in which hematopoietic precursors differentiate into DCs …

Alternatively activated microglia and macrophages in the central nervous system

R Franco, D Fernández-Suárez - Progress in neurobiology, 2015 - Elsevier
Macrophages are important players in the fight against viral, bacterial, fungal and parasitic
infections. From a resting state they may undertake two activation pathways, the classical …

Macrophages: development and tissue specialization

C Varol, A Mildner, S Jung - Annual review of immunology, 2015 - annualreviews.org
Macrophages are myeloid immune cells that are strategically positioned throughout the
body tissues, where they ingest and degrade dead cells, debris, and foreign material and …

The pathogenic role of angiogenesis in rheumatoid arthritis

HA Elshabrawy, Z Chen, MV Volin, S Ravella… - Angiogenesis, 2015 - Springer
Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

Role of innate and adaptive immune mechanisms in cardiac injury and repair

S Epelman, PP Liu, DL Mann - Nature Reviews Immunology, 2015 - nature.com
Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

[HTML][HTML] Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells

J Sheng, C Ruedl, K Karjalainen - Immunity, 2015 - cell.com
Macrophages are one of the most diverse cell populations in terms of their anatomical
location and functional specialization during both homeostasis and disease. Although it has …

The development and function of lung-resident macrophages and dendritic cells

M Kopf, C Schneider, SP Nobs - Nature immunology, 2015 - nature.com
Gas exchange is the vital function of the lungs. It occurs in the alveoli, where oxygen and
carbon dioxide diffuse across the alveolar epithelium and the capillary endothelium …

Origin of microglia: current concepts and past controversies

F Ginhoux, M Prinz - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Microglia are the resident macrophages of the central nervous system (CNS), which sit in
close proximity to neural structures and are intimately involved in brain homeostasis. The …