The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic illnesses
in the world. The disease encompasses emphysema, chronic bronchitis, and small airway …

Many organs throughout the body maintain epithelial homeostasis by employing a mucosal
barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells …

Epithelial cells that line the conducting airways provide the initial barrier and innate immune
responses to the abundant particles, microbes, and allergens that are inhaled throughout …

Pneumonia is initiated by microbes in the lung, but physiological processes integrating
responses across diverse cell types and organ systems dictate the outcome of respiratory …

Allergy and viral respiratory infections have long been recognized as two of the most
important risk factors for exacerbations of asthma. These observations have raised …

The scientific community has made great progress understanding the heterogeneity of
asthma through analysis of clinical, cellular, and molecular characteristics. We hypothesize …

Background Increased mucus production is a critical factor impairing lung function in
patients suffering from bronchial asthma, the most common chronic inflammatory lung …

Rhinovirus (RV) infections account for most asthma exacerbations among children and
adults, yet the fundamental mechanism responsible for why asthmatics are more susceptible …

Obesity and diabetes are major health concerns worldwide. Western diets, often calorically
rich, paired with sedentary habits are driving the current worldwide epidemic of pediatric and …