Proteomic database mining opens up avenues utilizing extracellular protein phosphorylation for novel therapeutic applications

G Yalak, BR Olsen - Journal of Translational Medicine, 2015 - Springer
Recent advances in extracellular signaling suggest that extracellular protein
phosphorylation is a regulatory mechanism outside the cell. The list of reported active …

Ectokinases as novel cancer markers and drug targets in cancer therapy

G Yalak, V Vogel - Cancer medicine, 2015 - Wiley Online Library
While small‐molecule kinase inhibitors became the most prominent anticancer drugs, novel
combinatorial strategies need to be developed as the fight against cancer is not yet won. We …

Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity

G Cozza, S Zanin, S Sarno, E Costa… - Biochemical …, 2015 - portlandpress.com
By derivatizing the purely competitive CK2 inhibitor N 1-(4, 5, 6, 7-tetrabromo-1 H-
benzimidazol-2-yl)-propane-1, 3-diamine (K137) at its 3-amino position with a peptidic …

Vitamin D3 prevents the increase in ectonucleotidase activities and ameliorates lipid profile in type 1 diabetic rats

NS Calgaroto, P Da Costa, AM Cardoso… - Molecular and Cellular …, 2015 - Springer
This study was designed to assess the potential effect of vitamin D 3 (VD 3) in avoiding
atherothrombosis by modulation of lipid metabolism and platelet activation in type 1 diabetic …

Signal transduction pathways of TNAP: molecular network analyses

L Négyessy, B Györffy, J Hanics, M Bányai… - Neuronal Tissue …, 2015 - Springer
Despite the growing body of evidence pointing on the involvement of tissue non-specific
alkaline phosphatase (TNAP) in brain function and diseases like epilepsy and Alzheimer's …

Role of Sperm Surface Molecules in Motility Regulation

GC MAJUMDER, S SAHA, K DAS… - Mammalian …, 2015 - taylorfrancis.com
Contents 8.1 Introduction............................................................................................. 198 8.2 Sperm
Motility Assays.............................................................................. 199 8.3 Isolation of Sperm …

[PDF][PDF] Massenspektrometrische Identifizierung extrazellulär phosphorylierter endothelialer Membranproteine

W Willberg - 2015 - docserv.uni-duesseldorf.de
Seit den 1970ger Jahren sind auf der Oberfläche von Zellen so gut wie aller Gewebe
Ektoproteinkinasen nachgewiesen worden. Die bis heute bekannten Substrate dieser …

Compositions and methods for causing neurite outgrowth

Y Takei - US Patent 9,089,565, 2015 - Google Patents
The invention relates to a method for alleviating the inhibition of neurite outgrowth from a
neurone, wherein said neurone comprises a Nogo receptor, said method comprising contact …