Network analysis represents a novel theoretical approach to personality. Network
approaches motivate alternative ways of analyzing data, and suggest new ways of modeling …

Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …

Transcriptional regulation and posttranscriptional processing underlie many cellular and
organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue …

During rest, brain activity is synchronized between different regions widely distributed
throughout the brain, forming functional networks. However, the molecular mechanisms …

The structure and function of the human brain are highly stereotyped, implying a conserved
molecular program responsible for its development, cellular structure and function. We …

Psychiatric disorders are characterized by major fluctuations in psychological function over
the course of weeks and months, but the dynamic characteristics of brain function over this …

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …

Recent studies implicate chromatin modifiers in autism spectrum disorder (ASD) through the
identification of recurrent de novo loss of function mutations in affected individuals. ASD risk …