Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …

Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …

Most variants implicated in common human disease by genome-wide association studies
(GWAS) lie in noncoding sequence intervals. Despite the suggestion that regulatory element …

Objective Vitamin D and the vitamin D receptor (VDR) appear to be important immunological
regulators of inflammatory bowel diseases (IBD). Defective autophagy has also been …

Mendelian randomization (MR) is an approach that uses genetic variants associated with a
modifiable exposure or biological intermediate to estimate the causal relationship between …

This review aimed to summarize the epidemiology (incidence, prevalence and morality) and
risk factors of inflammatory bowel disease (IBD). IBD is a chronic, relapsing, inflammatory …

Functional and morphological alterations of the intestinal epithelial barrier (IEB) have been
consistently reported in digestive disorders such as irritable bowel syndrome and …

Inflammatory Bowel Disease (IBD) represents a group of idiopathic disorders characterized
by chronic or recurring inflammation of the gastrointestinal tract. While the exact etiology of …

Mucosal immunity protects a host from intestinal inflammation and infection and is
profoundly influenced by symbiotic bacteria. Here we report that in mice symbiotic bacteria …