Regulation of ERK kinase by MEK1 kinase inhibition in the brain

TC Tassin, DR Benavides, F Plattner, A Nishi… - Journal of Biological …, 2015 - ASBMB
Metabotropic (slow) and ionotropic (fast) neurotransmission are integrated by intracellular
signal transduction mechanisms involving protein phosphorylation/dephosphorylation to …

Identification of para‐Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot

K Li, P Xiao, D Zhang, XB Hou, L Ge, D Yang… - …, 2015 - Wiley Online Library
Slingshot proteins form a small group of dual‐specific phosphatases that modulate
cytoskeleton dynamics through dephosphorylation of cofilin and Lim kinases (LIMK). Small …

Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression

M Erkens, K Tanaka-Yamamoto, G Cheron… - Molecular brain, 2015 - Springer
Background Regulation of synaptic connectivity, including long-term depression (LTD),
allows proper tuning of cellular signalling processes within brain circuitry. In the cerebellum …