Phytol in a pharma-medico-stance

MT Islam, MVOB de Alencar… - Chemico-Biological …, 2015 - Elsevier
This study aims to review phytol (PYT), through published articles, periodicals, magazines
and patents, which were retrieved from the PM, SD, WS, SP; DII, WIPO, CIPO, USPTO and …

Trifluoromethylpyrazoles as anti-inflammatory and antibacterial agents: A review

K Kaur, V Kumar, GK Gupta - Journal of Fluorine Chemistry, 2015 - Elsevier
In the recent past trifluoromethylpyrazoles have gained much attention, particularly as anti-
inflammatory and antibacterial agents, in the field of medicinal chemistry. The location of …

Photocatalytic Radical Trifluoromethylation/Cyclization Cascade: Synthesis of CF3-Containing Pyrazolines and Isoxazolines

Q Wei, JR Chen, XQ Hu, XC Yang, B Lu, WJ Xiao - Organic letters, 2015 - ACS Publications
A general visible light induced photoredox-catalyzed radical trifluoromethylation/cyclization
cascade of β-aryl-β, γ-unsaturated hydrazones and oximes is described. The protocol …

Bromine and water quality–Selected aspects and future perspectives

B Winid - Applied Geochemistry, 2015 - Elsevier
Bromine is a microelement present in waters, both in inorganic and in a wide range of
organic compounds, though at lower concentrations. Typically, concentrations of …

Synthesis and biological evaluation of novel Δ 2-isoxazoline fused cyclopentane derivatives as potential antimicrobial and anticancer agents

SK Prajapti, S Shrivastava, U Bihade, AK Gupta… - …, 2015 - pubs.rsc.org
As a part of our endeavour toward the synthesis of new heterocyclic bioactive agents, three
series of Δ2-isoxazoline fused cyclopentane derivatives (27 compounds) were synthesized …

Fluorinated isoxazolines and isoxazoles: A synthetic perspective

V Kumar, K Kaur - Journal of Fluorine Chemistry, 2015 - Elsevier
Isoxazoline and isoxazole derivatives are an important class of nitrogen and oxygen
containing heterocycles that are well known to display an array of various biological …

Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery

NC Tran, H Dhondt, M Flipo, B Deprez, N Willand - Tetrahedron letters, 2015 - Elsevier
The design of new sp 3 and spiro-enriched fragments has been achieved from 1, 3-dipolar
cycloaddition between alkenes and chloro-oximes. The selection of reagents was performed …

Design, synthesis and structure–activity relationship (SAR) studies of imidazo [4, 5-b] pyridine derived purine isosteres and their potential as cytotoxic agents

AM Sajith, KKA Khader, N Joshi, MN Reddy… - European Journal of …, 2015 - Elsevier
Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic
molecules which are active on MDR cancer cell lines. Regio-isomeric imidazo [4, 5-b] …

Chabamide induces cell cycle arrest and apoptosis by the Akt/MAPK pathway and inhibition of P-glycoprotein in K562/ADR cells

J Ren, Y Xu, Q Huang, J Yang, M Yang, K Hu… - Anti-Cancer …, 2015 - journals.lww.com
One of the major mechanisms of multidrug resistance in cancer therapy is the
overexpression of P-glycoprotein (P-gp). Chabamide, a dimeric alkaloid isolated from Piper …

Natural products as antibacterial agents—antibacterial potential and safety of post-distillation and waste material from Thymus vulgaris L., Lamiaceae

N Gavarić, J Kovač, N Kretschmer… - … , compounds and the …, 2015 - books.google.com
Medicinal plants have a long tradition of use in folk and conventional medicine. In recent
years numerous studies confirm various bioactivities of natural products, among them …