Approved drugs containing thiols as inhibitors of metallo-β-lactamases: strategy to combat multidrug-resistant bacteria
FM Klingler, TA Wichelhaus, D Frank… - Journal of medicinal …, 2015 - ACS Publications
Resistance to β-lactam antibiotics can be mediated by metallo-β-lactamase enzymes
(MBLs). An MBL inhibitor could restore the effectiveness of β-lactams. We report on the …
(MBLs). An MBL inhibitor could restore the effectiveness of β-lactams. We report on the …
Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)
E Wai-chiáChan - Chemical communications, 2015 - pubs.rsc.org
We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based
screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen …
screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen …
A novel partial agonist of peroxisome proliferator-activated receptor γ with excellent effect on insulin resistance and type 2 diabetes
Partial agonists of peroxisome proliferator–activated receptor γ (PPAR γ) reportedly reverse
insulin resistance in patients with type 2 diabetes mellitus. In this work, a novel non …
insulin resistance in patients with type 2 diabetes mellitus. In this work, a novel non …
[PDF][PDF] A novel partial agonist of PPARγ with excellent effect on insulin resistance and type 2 diabetes
H Liu, C Zhang, F Song, T Xiao, J Meng… - … of Pharmacology and …, 2015 - Citeseer
Partial agonists of peroxisome proliferator-activated receptor-γ (PPARγ) reportedly reverse
insulin resistance in patients with type 2 diabetes mellitus. In this work, a novel non …
insulin resistance in patients with type 2 diabetes mellitus. In this work, a novel non …
Entwicklung Orthogonaler Screening-Systeme für Metallo-β-Lactamasen und die sEH-Phosphatase
FM Klingler - 2015 - publikationen.ub.uni-frankfurt.de
Im Rahmen dieser Dissertation wurden drei bakterielle Enzyme, die Metallo-β-Lactamasen
NDM-1 (New Delhi Metallo-β-Lactamase 1), VIM-1 (Verona-Integron Encoded Metallo-β …
NDM-1 (New Delhi Metallo-β-Lactamase 1), VIM-1 (Verona-Integron Encoded Metallo-β …