Cancer stem cells (CSCs) represent a rare population of cells with the capacity to self-renew
and give rise to heterogeneous cell lineages within a tumour. Whilst the mechanisms …

It has been demonstrated that even localized tumors without clinically apparent metastasis
give rise to circulating tumor cells (CTCs). A growing number of technically diverse platforms …

CD133 and CXCR4 were evaluated in the NCI-60 cell lines to identify cancer stem cell rich
populations. Screening revealed that, ovarian OVCAR-3,-4 and-5 and colon cancer HT-29 …

Cancer stem cells (CSCs) have been proposed to underlie the initiation and maintenance of
tumor growth and the development of chemoresistance in solid tumors. The identification …

During recent years, it is becoming more and more evident that there is a tight connection
between abnormal differentiation processes and cancer. While cancer and stem cells are …

Cancer stem cells (CSCs) are a small subset of cells that may be responsible for initiation,
progression, and recurrence of tumors. Recent studies have demonstrated that CSCs are …

Tumor cell stemness has been recognized as a key contributor to tumor initiation,
progression and recurrence. Our previous studies have found that semaphorin-3F …

Pancreatic ductal adenocarcinoma (PDAC) contains a subset of exclusively tumorigenic
cancer stem cells (CSCs) which have been shown to drive tumor initiation, metastasis and …

A rare subpopulation of cancer cells known as cancer stem cells (CSCs) have distinct
characteristics resembling stem cells, including cell renewal capability, differentiation into …

Lung cancer is the leading cause of cancer-related mortality in humans. Exploration of the
mechanisms underlying the self-renewal and stemness maintenance of cancer stem-like …