Investigation of the salicylaldehyde thiosemicarbazone scaffold for inhibition of influenza virus PA endonuclease
D Rogolino, A Bacchi, L De Luca, G Rispoli… - JBIC Journal of …, 2015 - Springer
The influenza virus PA endonuclease is an attractive target for the development of novel anti-
influenza virus therapeutics, which are urgently needed because of the emergence of drug …
influenza virus therapeutics, which are urgently needed because of the emergence of drug …
Crucial role of PA in virus life cycle and host adaptation of influenza A virus
J Hu, X Liu - Medical Microbiology and Immunology, 2015 - Springer
The PA protein is the third subunit of the polymerase complex of influenza A virus.
Compared with the other two polymerase subunits (PB2 and PB1), its precise functions are …
Compared with the other two polymerase subunits (PB2 and PB1), its precise functions are …
An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease
The influenza virus PA endonuclease, which cleaves capped cellular pre-mRNAs to prime
viral mRNA synthesis, is a promising target for novel anti–influenza virus therapeutics. The …
viral mRNA synthesis, is a promising target for novel anti–influenza virus therapeutics. The …
Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase
S Fudo, N Yamamoto, M Nukaga, T Odagiri… - Bioorganic & Medicinal …, 2015 - Elsevier
Seasonal epidemics and occasional pandemics caused by influenza viruses are global
threats to humans. Since the efficacy of currently approved drugs is limited by the emerging …
threats to humans. Since the efficacy of currently approved drugs is limited by the emerging …
Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use
2015-06-18 Assigned to EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)
reassignment EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ASSIGNMENT …
reassignment EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) ASSIGNMENT …
[PDF][PDF] Conservational Analysis of Influenza A Virus RNA-dependent RNA Polymerase
V Darapaneni - American Journal of Current Microbiology, 2015 - Citeseer
The RNA-dependent RNA polymerase of influenza A virus is important for catalyzing the
replication and transcription of viral RNA. The polymerase of Influenza A Virus plays a …
replication and transcription of viral RNA. The polymerase of Influenza A Virus plays a …
[PDF][PDF] Identification and characterization of mammalian signatures of viral adaptation: a computational approach
A Marquardt - 2015 - core.ac.uk
Influenza viruses are single-stranded RNA (ssRNA) viruses, which are divided into three
distinct genera: A, B and C. Their genome is divided into eight segments. Whilst the …
distinct genera: A, B and C. Their genome is divided into eight segments. Whilst the …
Crystal structure of amino terminal portion of influenza virus polymerase PA subunit and use thereof
Y Liu, Z Rao - US Patent 9,017,960, 2015 - Google Patents
Present invention discloses the three-dimensional crystal structure of the N-terminus
polypeptide of influenza virus polymerase subunit (PA_N of SEQ ID NO: 7). PA_N of SEQ ID …
polypeptide of influenza virus polymerase subunit (PA_N of SEQ ID NO: 7). PA_N of SEQ ID …