Microorganisms are found throughout nature, thriving in a vast range of environmental
conditions. The majority of them are unculturable or difficult to culture by traditional methods …

Very few chemically novel agents have been approved for antibacterial chemotherapies
during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global …

Bacterial resistance to antibiotics continues to grow and pose serious challenges, while the
discovery rate for new antibiotics declines. Kibdelomycin is a recently discovered natural …

Diazo groups are found in a range of natural products that possess potent biological
activities. Despite longstanding interest in these metabolites, diazo group biosynthesis is not …

Yersinia pestis, the causative agent of bubonic, pneumonic and septicaemic plague,
remains a major public health threat, with outbreaks of disease occurring in China …

Platensimycin (PTM) and platencin (PTN) are members of a new class of promising drug
leads that target bacterial and mammalian fatty acid synthases. We previously cloned and …

Abstract The natural product (−)‐platencin is a potent antibacterial agent that exerts its
effects through a novel mode of action. As such, it is an important lead in the development of …

Delineating the mechanisms for genetically acquired antibiotic resistance is a robust
approach to target validation and anticipates the evolution of clinical drug resistance. This …

In bacterial type II fatty acid biosynthesis (FAS-II), β-ketoacyl-acyl carrier protein (ACP)
synthase III (FabH) initiates the first condensation of acyl-CoA and malonyl-ACP to form …

Platensimycin and platencin were successively discovered from the strain Streptomyces
platensis through systematic screening. These natural products have been defined as …