Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages

L Chávez-Galán, ML Olleros, D Vesin… - Frontiers in …, 2015 - frontiersin.org
Monocytes are considered to be precursor cells of the mononuclear phagocytic system, and
macrophages are one of the leading members of this cellular system. Macrophages play …

Macrophages: their emerging roles in bone

BP Sinder, AR Pettit, LK McCauley - Journal of Bone and …, 2015 - academic.oup.com
Macrophages are present in nearly all tissues and are critical for development, homeostasis,
and regeneration. Resident tissue macrophages of bone, termed osteal macrophages, are …

Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice

T Imai, Y Takahashi, M Nishikawa, K Kato… - Journal of …, 2015 - Taylor & Francis
Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-
LA), a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome …

Molecular mechanisms and novel therapeutic approaches to rhabdomyolysis-induced acute kidney injury

N Panizo, A Rubio-Navarro… - Kidney and Blood …, 2015 - karger.com
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to
acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including …

Burn induces browning of the subcutaneous white adipose tissue in mice and humans

D Patsouris, P Qi, A Abdullahi, M Stanojcic, P Chen… - Cell reports, 2015 - cell.com
Burn is accompanied by long-lasting immuno-metabolic alterations referred to as
hypermetabolism that are characterized by a considerable increase in resting energy …

Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs

SK Sharma, NK Chintala, SK Vadrevu… - The Journal of …, 2015 - journals.aai.org
In contrast to tumor-associated macrophages, myeloid-derived suppressor cells, or
inflammatory monocytes, functions of tissue resident macrophages, including alveolar …

Regulation of inflammation and fibrosis by macrophages in lymphedema

S Ghanta, DA Cuzzone, JS Torrisi… - American Journal …, 2015 - journals.physiology.org
Lymphedema, a common complication of cancer treatment, is characterized by
inflammation, fibrosis, and adipose deposition. We have previously shown that macrophage …

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage‐mediated inflammation in muscle

F Genêt, I Kulina, C Vaquette, F Torossian… - The Journal of …, 2015 - Wiley Online Library
Neurological heterotopic ossification (NHO) is the abnormal formation of bone in soft tissues
as a consequence of spinal cord or traumatic brain injury. NHO causes pain, ankyloses …

Intratumoral delivery of IL-21 overcomes anti-Her2/Neu resistance through shifting tumor-associated macrophages from M2 to M1 phenotype

M Xu, M Liu, X Du, S Li, H Li, X Li, Y Li… - The Journal of …, 2015 - journals.aai.org
Tumor resistance is a major hurdle to anti-Her2/neu Ab–based cancer therapy. Current
strategies to overcome tumor resistance focus on tumor cell–intrinsic resistance. However …

Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals

LI Chuan, J Zhang, ZU Yu-Jiao, NIE Shu-Fang… - Chinese journal of …, 2015 - Elsevier
Many phytochemicals show promise in cancer prevention and treatment, but their low
aqueous solubility, poor stability, unfavorable bioavailability, and low target specificity make …