[HTML][HTML] Analysis pipelines and packages for Infinium HumanMethylation450 BeadChip (450k) data

TJ Morris, S Beck - Methods, 2015 - Elsevier
Abstract The Illumina HumanMethylation450 BeadChip has become a popular platform for
interrogating DNA methylation in epigenome-wide association studies (EWAS) and related …

Sex differences in DNA methylation assessed by 450 K BeadChip in newborns

P Yousefi, K Huen, V Davé, L Barcellos, B Eskenazi… - BMC genomics, 2015 - Springer
Background DNA methylation is an important epigenetic mark that can potentially link early
life exposures to adverse health outcomes later in life. Host factors like sex and age strongly …

[HTML][HTML] The cerebellum ages slowly according to the epigenetic clock

S Horvath, V Mah, AT Lu, JS Woo, OW Choi… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Studies that elucidate why some human tissues age faster than others may shed light on
how we age, and ultimately suggest what interventions may be possible. Here we utilize a …

A systematic study of normalization methods for Infinium 450K methylation data using whole-genome bisulfite sequencing data

T Wang, W Guan, J Lin, N Boutaoui, G Canino, J Luo… - Epigenetics, 2015 - Taylor & Francis
DNA methylation plays an important role in disease etiology. The Illumina Infinium
HumanMethylation450 (450K) BeadChip is a widely used platform in large-scale …

quantro: a data-driven approach to guide the choice of an appropriate normalization method

SC Hicks, RA Irizarry - Genome biology, 2015 - Springer
Normalization is an essential step in the analysis of high-throughput data. Multi-sample
global normalization methods, such as quantile normalization, have been successfully used …

PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genes

K Huen, P Yousefi, K Street, B Eskenazi… - Environmental …, 2015 - academic.oup.com
Recent genome-and epigenome-wide studies demonstrate that the DNA methylation is
controlled in part by genetics, highlighting the importance of integrating genetic and …

A pooling-based approach to mapping genetic variants associated with DNA methylation

IM Kaplow, JL MacIsaac, SM Mah, LM McEwen… - Genome …, 2015 - genome.cshlp.org
DNA methylation is an epigenetic modification that plays a key role in gene regulation.
Previous studies have investigated its genetic basis by mapping genetic variants that are …

Relationship between expression and methylation of obesity-related genes in children

V Davé, P Yousefi, K Huen, V Volberg, N Holland - Mutagenesis, 2015 - academic.oup.com
Epigenetic control of gene expression in children remains poorly understood, but new
technologies can help elucidate the relationship between expression and DNA methylation …

A retrospective likelihood approach for efficient integration of multiple omics factors in case‐control association studies

B Balliu, R Tsonaka, S Boehringer… - Genetic …, 2015 - Wiley Online Library
Integrative omics, the joint analysis of outcome and multiple types of omics data, such as
genomics, epigenomics, and transcriptomics data, constitute a promising approach for …

[PDF][PDF] Statistical methods for genetic association studies with response-selective

B Balliu - Statistica Sinica - scholarlypublications …
Data transformations prior to analysis may be beneficial in classification tasks. In this article
we investigate a set of such transformations on 2D graph-data derived from facial images …