White matter hyperintensities (WMH) are commonly seen in the brain of healthy elderly
subjects and patients with several neurological and vascular disorders. A truly reliable and …

The evidence on the clinical significance of cerebral white matter changes (WMC) has
mounted over the past few decades. WMC are recognized as one of the neuroimaging …

White matter hyperintensities (WMH) of presumed vascular origin are a common finding in
brain magnetic resonance imaging of older individuals and contribute to cognitive and …

Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes
of presumed vascular origin, is common in elderly people and is related to cognitive …

Background and Purpose—White matter hyperintensities (WMH) are associated with
clinically heterogeneous symptoms that cannot be explained by these lesions alone. It is …

Background and Purpose—The relationships between cerebrovascular lesions visible on
imaging and cognition are complex. We explored the possibility that the cerebral cortical …

Background and Purpose—The blood–brain barrier (BBB) is disrupted in small vessel
disease patients with lacunes and white matter hyperintensities (WMHs). The relationship of …

Blood pressure (BP) variability is associated with stroke risk, but less is known about
subclinical cerebral small vessel disease (CSVD). We aimed to determine whether CSVD …

Background and Purpose—In patients with subjective cognitive decline, we assessed
whether small vessel disease was associated with clinical progression and cognitive …

Background and Purpose—The term metabolic syndrome describes the clustering of risk
factors found in many individuals with obesity. Because of their pathophysiology, we …