[HTML][HTML] The hunger genes: pathways to obesity
AA Van der Klaauw, IS Farooqi - Cell, 2015 - cell.com
The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …
Genetic variation and the de novo assembly of human genomes
The discovery of genetic variation and the assembly of genome sequences are both
inextricably linked to advances in DNA-sequencing technology. Short-read massively …
inextricably linked to advances in DNA-sequencing technology. Short-read massively …
Rare and common genetic events in type 2 diabetes: what should biologists know?
A Bonnefond, P Froguel - Cell metabolism, 2015 - cell.com
Type 2 diabetes (T2D) had long been referred to as the" geneticist's nightmare." Genome-
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …
wide association studies have fully confirmed the polygenic nature of T2D, demonstrating …
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity
Hundreds of genes reside in structurally complex, poorly understood regions of the human
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …
Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes
D Carpenter, S Dhar, LM Mitchell, B Fu… - Human molecular …, 2015 - academic.oup.com
The human salivary amylase genes display extensive copy number variation (CNV), and
recent work has implicated this variation in adaptation to starch-rich diets, and in association …
recent work has implicated this variation in adaptation to starch-rich diets, and in association …
Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children
MA Mejía-Benítez, A Bonnefond, L Yengo, M Huyvaert… - Diabetologia, 2015 - Springer
Aims/hypothesis Childhood obesity is a major public health problem in Mexico, affecting one
in every three children. Genome-wide association studies identified genetic variants …
in every three children. Genome-wide association studies identified genetic variants …
Salivary amylase–The enzyme of unspecialized euryphagous animals
C Boehlke, O Zierau, C Hannig - Archives of oral biology, 2015 - Elsevier
Abstract Introduction Alpha-amylase (EC 3.2. 1.1) is the most abundant enzyme in the saliva
of man and of several vertebrates. In humans, salivary amylase is mainly formed in the …
of man and of several vertebrates. In humans, salivary amylase is mainly formed in the …
Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland
H Viljakainen, JC Andersson-Assarsson, M Armenio… - PloS one, 2015 - journals.plos.org
Background The salivary α-amylase locus (AMY1) is located in a highly polymorphic multi
allelic copy number variable chromosomal region. A recent report identified an association …
allelic copy number variable chromosomal region. A recent report identified an association …
Complex and multi-allelic copy number variation in human disease
CL Usher, SA McCarroll - Briefings in functional genomics, 2015 - academic.oup.com
Hundreds of copy number variants are complex and multi-allelic, in that they have many
structural alleles and have rearranged multiple times in the ancestors who contributed …
structural alleles and have rearranged multiple times in the ancestors who contributed …
Association between salivary amylase (AMY1) gene copy numbers and insulin resistance in asymptomatic Korean men
Aims Salivary amylase gene (AMY 1) copy number variations (CNV s) correlate directly with
salivary amylase activity and serum amylase levels. Previously, individuals with high AMY 1 …
salivary amylase activity and serum amylase levels. Previously, individuals with high AMY 1 …