DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …
HIV-1 infection accelerates age according to the epigenetic clock
S Horvath, AJ Levine - The Journal of infectious diseases, 2015 - academic.oup.com
Background. Infection with human immunodeficiency virus type 1 (HIV) is associated with
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …
clinical symptoms of accelerated aging, as evidenced by the increased incidence and …
[HTML][HTML] Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning
There is an urgent need to develop molecular biomarkers of brain age in order to advance
our understanding of age related neurodegeneration. Recently, we developed a highly …
our understanding of age related neurodegeneration. Recently, we developed a highly …
The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936
Background: The DNA methylation-based 'epigenetic clock'correlates strongly with
chronological age, but it is currently unclear what drives individual differences. We examine …
chronological age, but it is currently unclear what drives individual differences. We examine …
[HTML][HTML] Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients
It has been a long standing hypothesis that blood tissue of PD Parkinson's disease (PD)
patients may exhibit signs of accelerated aging. Here we use DNA methylation based …
patients may exhibit signs of accelerated aging. Here we use DNA methylation based …
[HTML][HTML] Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
S Horvath, C Pirazzini, MG Bacalini, D Gentilini… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Given the dramatic increase in ageing populations, it is of great importance to understand
the genetic and molecular determinants of healthy ageing and longevity. Semi …
the genetic and molecular determinants of healthy ageing and longevity. Semi …
Development of a forensically useful age prediction method based on DNA methylation analysis
R Zbieć-Piekarska, M Spólnicka, T Kupiec… - Forensic Science …, 2015 - Elsevier
Forensic DNA phenotyping needs to be supplemented with age prediction to become a
relevant source of information on human appearance. Recent progress in analysis of the …
relevant source of information on human appearance. Recent progress in analysis of the …
[HTML][HTML] DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative
Lung cancer is considered an age-associated disease, whose progression is in part due to
accumulation of genomic instability as well as age-related decline in system integrity and …
accumulation of genomic instability as well as age-related decline in system integrity and …
[HTML][HTML] Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
Background Chronic psychological stress is associated with accelerated aging and
increased risk for aging-related diseases, but the underlying molecular mechanisms are …
increased risk for aging-related diseases, but the underlying molecular mechanisms are …