Early in the HIV epidemic, the central nervous system (CNS) was recognized as a target of
infection and injury in the advanced stages of disease. Though the most severe forms of HIV …

CNS infection is a nearly constant facet of systemic CNS infection and is generally well
controlled by suppressive systemic antiretroviral therapy (ART). However, there are …

Controversy exists as to whether the central nervous system (CNS) serves as a reservoir site
for HIV, in part reflecting the varying perspectives on what constitutes a 'reservoir'versus a …

Apathy remains a common neuropsychiatric disturbance in the Human Immunodeficiency
Virus (HIV-1) despite advances in anti-retroviral treatment (ART). The goal of the current …

Antiretroviral concentrations in cerebrospinal fluid (CSF) are variable; darunavir and
efavirenz show levels several times higher than HIV-1 95% inhibitory concentrations (IQ95) …

Neuro-AIDS is becoming a major health problem among AIDS patients who experience
improved survival under combined antiretroviral therapy (cART). Neuronal injury and loss …

Objectives: To identify differentially expressed (DE) genes in HIV-associated neurocognitive
disorders (HAND) patients in comparison with HIV-infected patients without HAND and …

Antiretroviral drugs may help prevent neurological decline in individuals with HIV infection
by suppressing viral replication and associated chronic immune activation in the central …

It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND)
and other types of neurocognitive disease in the ageing HIV-infected population. Here we …

Background Limited data exist comparing viral quasispecies between cerebrospinal fluid
(CSF) and plasma compartments during primary HIV infection. Deep sequencing is a new …