The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

A number of small molecules with the ability to extend the lifespan of multiple organisms
have recently been discovered. Resveratrol, amongst the most prominent of these, has …

Examples of extrachromosomal circular DNAs (eccDNAs) are found in many organisms, but
their impact on genetic variation at the genome scale has not been investigated. We …

Epigenetic mechanisms, including histone post-translational modifications, control longevity
in diverse organisms. Relatedly, loss of proper transcriptional regulation on a global scale is …

The silent mating type information regulation 2 proteins (sirtuins) 1 of class III histone
deacetylases (HDACs) have been associated with health span and longevity. SIRT1, the …

Differentiation of cellular lineages is facilitated by asymmetric segregation of fate
determinants between dividing cells. In budding yeast, various aging factors segregate to …

Although there are seven mammalian sirtuins (SIRT1-7), little is known about their
expression in the aging brain. To characterize the change (s) in mRNA and protein …

Dietary restriction (DR) attenuates many detrimental effects of aging and consequently
promotes health and increases longevity across organisms. While over the last 15 years …

The mechanisms underlying biological aging have been extensively studied in the past 20
years with the avail of mainly four model organisms: the budding yeast Saccharomyces …

DNA replication initiates at defined replication origins along eukaryotic chromosomes,
ensuring complete genome duplication within a single S-phase. A key feature of replication …