Losartan treatment protects retinal ganglion cells and alters scleral remodeling in experimental glaucoma

HA Quigley, IF Pitha, DS Welsbie, C Nguyen… - PLoS …, 2015 - journals.plos.org
Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC)
death caused by experimental intraocular pressure (IOP) elevation in mice. Methods We …

Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1)

AY Shanab, SL Elshaer, MF El-Azab, S Soliman… - Angiogenesis, 2015 - Springer
Ischemic diseases such as stroke and proliferative retinopathy are characterized by hypoxia-
driven release of angiogenic factors such as vascular endothelial growth factor (VEGF) …

[HTML][HTML] Adenosine A1 receptors selectively modulate oxygen-induced retinopathy at the hyperoxic and hypoxic phases by distinct cellular mechanisms

S Zhang, H Li, B Li, D Zhong, X Gu, L Tang… - … & Visual Science, 2015 - arvojournals.org
Purpose: We critically evaluated the role of the adenosine A 1 receptor (A 1 R) in normal
development of retinal vasculature and pathogenesis of retinopathy of prematurity (ROP) by …

[HTML][HTML] Ocular renin-angiotensin system with special reference in the anterior part of the eye

M Holappa, H Vapaatalo, A Vaajanen - World Journal of Ophthalmology, 2015 - wjgnet.com
The renin-angiotensin system (RAS) regulates blood pressure (BP) homeostasis, systemic
fluid volume and electrolyte balance. The RAS cascade includes over twenty peptidases …

肾素-血管紧张素-醛固酮系统在眼科疾病中的研究进展

刘野, 赵江月, 张劲松 - 解放军医药杂志, 2015 - cqvip.com
自从1898 年Tigerstedt R 等发现肾素以来, 对肾素-血管紧张素-醛固酮系统(renin-
angiotensinaldosterone system, RAAS) 的研究已有近百年的历史. 由于其在调节血压和维持 …