EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes
methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target …

Lysine methylation is a common posttranslational modification (PTM) of histones that is
important for the epigenetic regulation of transcription and chromatin in eukaryotes …

Summary Polycomb Group (PcG) proteins maintain transcriptional repression throughout
development, mostly by regulating chromatin structure. Polycomb Repressive Complex 2 …

Rationale: Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers
great opportunities for cardiac disease modeling and cardiac regeneration. A major …

A cytosolic role for the histone methyltransferase Ezh2 in regulating lymphocyte activation
has been suggested, but the molecular mechanisms underpinning this extranuclear function …

Background Tumor metastasis is responsible for 90% of cancer-related deaths. Recently, a
strong link between microRNA dysregulation and human cancers has been established …

Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same
enzymes that also modify histones, with important functional consequences. We have …

Distinctive patterns of chromatin modification control gene expression and define cellular
identity during development and cell differentiation. Polycomb repressive complex 2 (PRC2) …

Transcriptional regulation of thousands of genes instructs complex morphogenetic and
molecular events for heart development. Cardiac transcription factors choreograph gene …

Bladder Cancer (BC) represents a current clinical and social challenge. The recent studies
aimed to describe the genomic landscape of BC have underscored the relevance of …