Genetics and genomics of psychiatric disease

DH Geschwind, J Flint - Science, 2015 - science.org
Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

Genetic studies of schizophrenia: an update

J Chen, F Cao, L Liu, L Wang, X Chen - Neuroscience bulletin, 2015 - Springer
Schizophrenia (SCZ) is a complex and heterogeneous mental disorder that affects about 1%
of global population. In recent years, considerable progress has been made in genetic …

New discoveries in schizophrenia genetics reveal neurobiological pathways: a review of recent findings

AV Kotlar, KB Mercer, ME Zwick, JG Mulle - European journal of medical …, 2015 - Elsevier
Schizophrenia research has undergone a recent transformation. By leveraging large sample
sizes, genome-wide association studies of common genetic variants have approximately …

Integrated Genome-wide association and hypothalamus eQTL studies indicate a link between the circadian rhythm-related gene PER1 and coping behavior

S Ponsuksili, M Zebunke, E Murani, N Trakooljul… - Scientific Reports, 2015 - nature.com
Animal personality and coping styles are basic concepts for evaluating animal welfare.
Struggling response of piglets in so-called backtests early in life reflects their coping …

Identification of rare, single-nucleotide mutations in NDE1 and their contributions to schizophrenia susceptibility

H Kimura, D Tsuboi, C Wang, I Kushima… - Schizophrenia …, 2015 - academic.oup.com
Background: Nuclear distribution E homolog 1 (NDE1), located within chromosome 16p13.
11, plays an essential role in microtubule organization, mitosis, and neuronal migration and …

Copy number variations in DISC1 and DISC1-interacting partners in major mental illness

M Johnstone, A Maclean, L Heyrman, AS Lenaerts… - Complex …, 2015 - karger.com
Robust statistical, genetic and functional evidence supports a role for DISC1 in the aetiology
of major mental illness. Furthermore, many of its protein-binding partners show evidence for …

A maternally inherited 16p13.11‐p12.3 duplication concomitant with a de novo SOX5 deletion in a male patient with global developmental delay, disruptive and …

I Quintela, F Barros, R Lago‐Leston… - American Journal of …, 2015 - Wiley Online Library
We detail here the clinical description and the family genetic study of a male patient with
global developmental delay, disruptive and obsessive behaviors and minor dysmorphic …

A genome-wide copy number variant study of suicidal behavior

JA Gross, A Bureau, J Croteau, H Galfalvy… - PloS one, 2015 - journals.plos.org
Suicide and suicide attempts are complex behaviors that result from the interaction of
different factors, including genetic variants that increase the predisposition to suicidal …

RNA sequencing in schizophrenia

X Li, S Teng - Bioinformatics and biology insights, 2015 - journals.sagepub.com
Schizophrenia (SCZ) is a serious psychiatric disorder that affects 1% of general population
and places a heavy burden worldwide. The underlying genetic mechanism of SCZ remains …

Homozygous 16p13. 11 duplication associated with mild intellectual disability and urinary tract malformations in two siblings born from consanguineous parents

N Houcinat, B Llanas, S Moutton… - American Journal of …, 2015 - Wiley Online Library
The use of array‐comparative genomic hybridization (array‐CGH) in routine clinical work
has allowed the identification of many new copy number variations (CNV). The 16p13. 11 …