Congenital anomalies of the kidney and urinary tract (CAKUT) refer to a spectrum of
structural renal malformations and are the leading cause of end-stage renal disease in …

Diabetes is characterized by altered metabolism of key molecules and regulatory pathways.
The phenotypic expression of diabetes and associated complications encompasses …

Kidney fibrosis is marked by an epithelial-to-mesenchymal transition (EMT) of tubular
epithelial cells (TECs). Here we find that, during renal fibrosis, TECs acquire a partial EMT …

Background A main challenge for targeting chronic kidney disease (CKD) is the
heterogeneity of its causes, co-morbidities and outcomes. Patients under nephrological care …

We developed a new statistical framework to find genetic variants associated with extreme
longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large …

Genome-wide association studies (GWASs) have identified multiple loci associated with
cross-sectional eGFR, but a systematic genetic analysis of kidney function decline over time …

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease
(CKD) in the industrialized world and accounts for much of the excess mortality in patients …

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic
disease and mortality, although little is known about the genetic variants influencing this trait …

GCKR variants across the allelic spectrum have effects on glucose and lipid homeostasis.
Functional analysis has highlighted numerous molecular mechanisms for GKRP …

Gout is one of the most common types of inflammatory arthritis, caused by the deposition of
monosodium urate crystals in and around the joints. Previous genome-wide association …