Modeling psychiatric disorders for developing effective treatments

T Kaiser, G Feng - Nature medicine, 2015 - nature.com
Recent advances in identifying risk-associated genes have provided unprecedented
opportunities for developing animal models for psychiatric disease research with the goal of …

Myelin, myelin-related disorders, and psychosis

MI Mighdoll, R Tao, JE Kleinman, TM Hyde - Schizophrenia research, 2015 - Elsevier
The neuropathological basis of schizophrenia and related psychoses remains elusive
despite intensive scientific investigation. Symptoms of psychosis have been reported in a …

Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation

D Avramopoulos, BD Pearce, J McGrath, P Wolyniec… - PloS one, 2015 - journals.plos.org
Inflammation and maternal or fetal infections have been suggested as risk factors for
schizophrenia (SZ) and bipolar disorder (BP). It is likely that such environmental effects are …

What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review

R Gurung, DP Prata - Psychological medicine, 2015 - cambridge.org
The powerful genome-wide association studies (GWAS) revealed common mutations that
increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority …

Childhood trauma as a risk factor for psychosis: A sib-pair study

ML Barrigón, FJ Diaz, M Gurpegui, M Ferrin… - Journal of psychiatric …, 2015 - Elsevier
Background Childhood trauma, cannabis use and certain personality traits have been
related to the development of psychosis. This study uses a sib-pair design to examine the …

New discoveries in schizophrenia genetics reveal neurobiological pathways: a review of recent findings

AV Kotlar, KB Mercer, ME Zwick, JG Mulle - European journal of medical …, 2015 - Elsevier
Schizophrenia research has undergone a recent transformation. By leveraging large sample
sizes, genome-wide association studies of common genetic variants have approximately …

Associating schizophrenia, long non-coding RNAs and neurostructural dynamics

V Merelo, D Durand, AR Lescallette… - Frontiers in molecular …, 2015 - frontiersin.org
Several lines of evidence indicate that schizophrenia has a strong genetic component. But
the exact nature and functional role of this genetic component in the pathophysiology of this …

Large-scale fusion of gray matter and resting-state functional MRI reveals common and distinct biological markers across the psychosis spectrum in the B-SNIP cohort

Z Wang, SA Meda, MS Keshavan… - Frontiers in …, 2015 - frontiersin.org
To investigate whether aberrant interactions between brain structure and function present
similarly or differently across probands with psychotic illnesses [schizophrenia (SZ) …

Mitochondrial dysfunction in schizophrenia: an evolutionary perspective

VF Gonçalves, AC Andreazza, JL Kennedy - Human genetics, 2015 - Springer
Schizophrenia (SCZ) is a severe psychiatric illness with a lifetime prevalence of 0.4%. A
disturbance of energy metabolism has been suggested as part of the etiopathogenesis of …

Early life and oxidative stress in psychiatric disorders: what can we learn from animal models?

E Mhillaj, M Grazia Morgese… - Current pharmaceutical …, 2015 - ingentaconnect.com
Schizophrenia is a complex pathology characterized by the occurrence of a variety of
symptoms classified as positive, negative and cognitive. Although the exact …