Machine learning in genomic medicine: a review of computational problems and data sets
In this paper, we provide an introduction to machine learning tasks that address important
problems in genomic medicine. One of the goals of genomic medicine is to determine how …
problems in genomic medicine. One of the goals of genomic medicine is to determine how …
Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes
AP Arruda, GS Hotamisligil - Cell metabolism, 2015 - cell.com
A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular
disease, asthma, and cancer, cluster together to present the greatest threat to human health …
disease, asthma, and cancer, cluster together to present the greatest threat to human health …
Genetic studies of body mass index yield new insights for obesity biology
AE Locke, B Kahali, SI Berndt, AE Justice, TH Pers… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta …
obesity better, here we conduct a genome-wide association study and Metabochip meta …
The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study
TW Winkler, AE Justice, M Graff, L Barata… - PLoS …, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI …
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI …
Leveraging functional-annotation data in trans-ethnic fine-mapping studies
G Kichaev, B Pasaniuc - The American Journal of Human Genetics, 2015 - cell.com
Localization of causal variants underlying known risk loci is one of the main research
challenges following genome-wide association studies. Risk loci are typically dissected …
challenges following genome-wide association studies. Risk loci are typically dissected …
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
S Voisin, MS Almén, GY Zheleznyakova, L Lundberg… - Genome medicine, 2015 - Springer
Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …
Shaping fat distribution: new insights into the molecular determinants of depot‐and sex‐dependent adipose biology
SK Fried, MJ Lee, K Karastergiou - Obesity, 2015 - Wiley Online Library
Objective To review recent advances in understanding the cellular mechanisms that
regulate fat distribution. Methods In this review, new insights into depot and sex differences …
regulate fat distribution. Methods In this review, new insights into depot and sex differences …
Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples
D Janowitz, K Wittfeld, J Terock, HJ Freyberger… - Neuroimage, 2015 - Elsevier
We analyzed the putative association between abdominal obesity (measured in waist
circumference) and gray matter volume (Study of Health in Pomerania: SHIP-2, N= 758) …
circumference) and gray matter volume (Study of Health in Pomerania: SHIP-2, N= 758) …
Neuroinflammation and comorbidities are frequently ignored factors in CNS pathology
RE Sandu, AM Buga, A Uzoni, EB Petcu… - Neural regeneration …, 2015 - journals.lww.com
Virtually all drug interventions that have been successful pre-clinically in experimental stroke
have failed to prove their efficacy in a clinical setting. This could be partly explained by the …
have failed to prove their efficacy in a clinical setting. This could be partly explained by the …