The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo
W Gao, JY Kim, JR Anderson, T Akopian… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Drug-resistant tuberculosis (TB) has lent urgency to finding new drug leads with novel
modes of action. A high-throughput screening campaign of> 65,000 actinomycete extracts …
modes of action. A high-throughput screening campaign of> 65,000 actinomycete extracts …
Gift from nature: Cyclomarin A kills mycobacteria and malaria parasites by distinct modes of action
N Bürstner, S Roggo, N Ostermann, J Blank… - …, 2015 - Wiley Online Library
Malaria continues to be one of the most devastating human diseases despite many efforts to
limit its spread by prevention of infection or by pharmaceutical treatment of patients. We …
limit its spread by prevention of infection or by pharmaceutical treatment of patients. We …
Structures, functions, and interactions of ClpT1 and ClpT2 in the Clp protease system of Arabidopsis chloroplasts
Abstract Plastid ClpT1 and ClpT2 are plant-specific proteins that associate with the ClpPR
protease. However, their physiological significance and structures are not understood …
protease. However, their physiological significance and structures are not understood …
[PDF][PDF] RETRACTED: Targeting Mycobacterial Enzymes with Natural Products
E Sieniawska - Chemistry & Biology, 2015 - cell.com
Tuberculosis (TB) is a recurring threat to contemporary civilization. It affects not only those
within developing countries, but has also appeared again in places where it was once …
within developing countries, but has also appeared again in places where it was once …
Synthesis of fully protected, reverse N-prenylated (2 S, 3 R)-3-hydroxytryptophan, a unique building block of the cyclomarins
P Barbie, U Kazmaier - Organic & Biomolecular Chemistry, 2015 - pubs.rsc.org
Reverse N-prenylated 3-hydroxytryptophan, the rather exotic amino acid of the cyclomarins,
is obtained in enantio-and diastereomerically pure and fully protected form by a combination …
is obtained in enantio-and diastereomerically pure and fully protected form by a combination …