Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia

Y Xin, X Jiang, Y Wang, X Su, M Sun, L Zhang, Y Tan… - PloS one, 2016 - journals.plos.org
Background The two major obstacles in the successful transplantation of islets for diabetes
treatment are inadequate supply of insulin-producing tissue and immune rejection. Induction …

Graphene-augmented nanofiber scaffolds demonstrate new features in cells behaviour

J Kazantseva, R Ivanov, M Gasik, T Neuman… - Scientific reports, 2016 - nature.com
Abstract Three-dimensional (3D) customized scaffolds capable to mimic a native
extracellular matrix open new frontiers in cells manipulation and advanced therapy. The …

[HTML][HTML] Global profiling of the gene expression and alternative splicing events during hypoxia-regulated chondrogenic differentiation in human cartilage endplate …

Y Yao, J Shang, W Song, Q Deng, H Liu, Y Zhou - Genomics, 2016 - Elsevier
The intervertebral disc (IVD) degeneration is initiated by cartilage endplate (CEP)
degeneration and is characterised by reduced chondrification. Cartilage endplate-derived …

Targeted alternative splicing of TAF4: a new strategy for cell reprogramming

J Kazantseva, H Sadam, T Neuman, K Palm - Scientific Reports, 2016 - nature.com
Reprogramming of somatic cells has become a versatile tool for biomedical research and for
regenerative medicine. In the current study, we show that manipulating alternative splicing …

A genome wide analysis of alternative splicing events during the osteogenic differentiation of human cartilage endplate-derived stem cells

J Shang, H Wang, X Fan… - Molecular medicine …, 2016 - spandidos-publications.com
Low back pain is a prevalent disease, which leads to suffering and disabilities in a vast
number of individuals. Degenerative disc diseases are usually the underlying causes of low …