[HTML][HTML] The biology and function of exosomes in cancer

R Kalluri - The Journal of clinical investigation, 2016 - Am Soc Clin Investig
Humans circulate quadrillions of exosomes at all times. Exosomes are a class of
extracellular vesicles released by all cells, with a size range of 40–150 nm and a lipid …

Tumor-derived exosomes and their role in cancer progression

TL Whiteside - Advances in clinical chemistry, 2016 - Elsevier
Tumor cells actively produce, release, and utilize exosomes to promote tumor growth.
Mechanisms through which tumor-derived exosomes subserve the tumor are under intense …

Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype

L Li, C Li, S Wang, Z Wang, J Jiang, W Wang, X Li… - Cancer research, 2016 - AACR
Hypoxia is a common feature of solid tumors and is associated with aggressiveness and
poor patient outcomes. Exosomes, initially considered to be cellular “garbage dumpsters,” …

[HTML][HTML] The hypoxic tumor microenvironment: A driving force for breast cancer progression

GL Semenza - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2016 - Elsevier
Intratumoral hypoxia is a common finding in breast cancer and is associated with a
significantly increased risk of metastasis and patient mortality. Hypoxia-inducible factors …

[HTML][HTML] Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers

SN Hurwitz, MA Rider, JL Bundy, X Liu, RK Singh… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Packed with biological information, extracellular vesicles (EVs) offer exciting promise for
biomarker discovery and applications in therapeutics and non-invasive diagnostics …

STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells

Y Liu, F Luo, B Wang, H Li, Y Xu, X Liu, L Shi, X Lu… - Cancer letters, 2016 - Elsevier
Although microRNA (miRNA) enclosed in exosomes can mediate intercellular
communication, the roles of exosomal miRNA and angiogenesis in lung cancer remain …

Adipose-derived stem cells induce angiogenesis via microvesicle transport of miRNA-31

T Kang, TM Jones, C Naddell… - Stem cells …, 2016 - academic.oup.com
Cell secretion is an important mechanism for stem cell-based therapeutic angiogenesis,
along with cell differentiation to vascular endothelial cells or smooth muscle cells. Cell …

Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis via EMMPRIN

KR Vrijsen, JA Maring, SAJ Chamuleau… - Advanced …, 2016 - Wiley Online Library
To date, cellular transplantation therapy has not yet fulfilled its high expectations for cardiac
repair. A major limiting factor is lack of long‐term engraftment of the transplanted cells …

[HTML][HTML] Exosomes derived from squamous head and neck cancer promote cell survival after ionizing radiation

L Mutschelknaus, C Peters, K Winkler, R Yentrapalli… - PloS one, 2016 - journals.plos.org
Exosomes are nanometer-sized extracellular vesicles that are believed to function as
intercellular communicators. Here, we report that exosomes are able to modify the radiation …

Nanoparticle analysis sheds budding insights into genetic drivers of extracellular vesicle biogenesis

SN Hurwitz, MM Conlon, MA Rider… - Journal of …, 2016 - Taylor & Francis
Background Extracellular vesicles (EVs) are important mediators of cell-to-cell
communication in healthy and pathological environments. Because EVs are present in a …