Macrophage phenotype and function in different stages of atherosclerosis
I Tabas, KE Bornfeldt - Circulation research, 2016 - Am Heart Assoc
The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …
Abandoning M1/M2 for a network model of macrophage function
M Nahrendorf, FK Swirski - Circulation research, 2016 - Am Heart Assoc
Regardless of how it arose, is there a problem with the current M1/M2 model? For one, the
concept is an in vitro construction that relies on stimulating macrophages in culture with a …
concept is an in vitro construction that relies on stimulating macrophages in culture with a …
Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure
Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …
Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth
Resident macrophages densely populate the normal arterial wall, yet their origins and the
mechanisms that sustain them are poorly understood. Here we use gene-expression …
mechanisms that sustain them are poorly understood. Here we use gene-expression …
OsteoMacs: Key players around bone biomaterials
RJ Miron, DD Bosshardt - Biomaterials, 2016 - Elsevier
Osteal macrophages (OsteoMacs) are a special subtype of macrophage residing in bony
tissues. Interesting findings from basic research have pointed to their vast and substantial …
tissues. Interesting findings from basic research have pointed to their vast and substantial …
Leukocytes link local and systemic inflammation in ischemic cardiovascular disease: an expanded “cardiovascular continuum”
Physicians have traditionally viewed ischemic heart disease in a cardiocentric manner:
plaques grow in arteries until they block blood flow, causing acute coronary and other …
plaques grow in arteries until they block blood flow, causing acute coronary and other …
[HTML][HTML] Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo
S Bekkering, I van den Munckhof, T Nielen, E Lamfers… - Atherosclerosis, 2016 - Elsevier
Background and aims We have recently reported that monocytes can undergo functional
and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after …
and transcriptional reprogramming towards a long-term pro-inflammatory phenotype after …
Do the Apoe−/− and Ldlr−/– Mice Yield the Same Insight on Atherogenesis?
GS Getz, CA Reardon - Arteriosclerosis, thrombosis, and vascular …, 2016 - Am Heart Assoc
Murine models of atherosclerosis are useful for investigating the environmental and genetic
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …
influences on lesion formation and composition. Apoe−/− and Ldlr−/− mice are the 2 most …
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
I Theurl, I Hilgendorf, M Nairz, P Tymoszuk… - Nature medicine, 2016 - nature.com
Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to
oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium …
oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium …
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and
humans, resulting in secondary ischemic complications and high mortality. We show that, in …
humans, resulting in secondary ischemic complications and high mortality. We show that, in …