Synapses are specialized structures that mediate rapid and efficient signal transmission
between neurons and are surrounded by glial cells. Astrocytes develop an intimate …

Rapidly emerging evidence implicates perineuronal nets (PNNs) and extracellular matrix
(ECM) molecules that compose or interact with PNNs, in the pathophysiology of several …

Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum
rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets …

Perineuronal nets (PNNs) are specialized complexes of extracellular matrix molecules that
surround the somata of fast-spiking neurons throughout the vertebrate brain. PNNs are …

Background Quantification of synapses and their morphological analysis are extensively
used in network development and connectivity studies, drug screening and other areas of …

Inhibition plays an important role in shaping responses to stimuli throughout the CNS,
including in the inferior colliculus (IC), a major hub in both ascending and descending …

The brain extracellular matrix (ECM) occupies the space between cells and is involved in
cell–matrix and cell–cell adhesion. However, in addition to providing structural support to …

Perineuronal nets (PNNs) are enigmatic structures composed of extracellular matrix
molecules that encapsulate the soma, dendrites, and axon segments of neurons in a lattice …

In brains of higher vertebrates, the delicate balance of structural remodeling and
stabilization of neuronal networks changes over the life-span. While the juvenile brain is …

We investigated possible interaction between an arbovirus infection and the ME7 induced
mice prion disease. C57BL/6, females, 6‐week‐old, were submitted to a bilateral …