Psoriasis is a chronic inflammatory autoimmune disease characterized by an excessively
aberrant hyperproliferation of keratinocytes. The pathogenesis of psoriasis is complex and …

Autoimmune diseases have a multifactorial etiology including genetic and environmental
factors. Recently, there has been increased appreciation of the critical involvement of the …

The human major histocompatibility complex (MHC) region has been shown to be
associated with numerous diseases. However, it remains a challenge to pinpoint the causal …

Psoriasis encompasses a group of related immune‐mediated inflammatory skin diseases
that affect up to 3% of the population. These diseases are heritable and over 40 genetic …

Although genome-wide association studies have revealed important insights into the global
genetic basis of psoriasis, the findings require further investigation. At present, the known …

HLA-Cw6 is one of the most associated alleles in psoriasis. Recently, Late Cornified
Envelop 3 (LCE3) genes were identified as a susceptibility factor for psoriasis. Some …

Psoriasis is a complex genetic disease, which has previously been associated with
numerous single nucleotide polymorphisms (SNPs) that are implicated in various processes …

Background Deletion of the late cornified envelope (LCE) proteins LCE3B and LCE3C is a
strong and widely replicated psoriasis risk factor. It is amenable to biological analysis …

Background: Previous studies have shown that individuals with schizophrenia have a
greater risk for psoriasis than a typical person. This suggests that there might be a shared …

Dermatomyositis (DM) is a polygenic disorder characterized by inflammation of skeletal
muscle and skin. To date, the exact etiopathogenesis of DM remains elusive. To explore the …