Human metabolites of cannabidiol: a review on their formation, biological activity, and relevance in therapy

I Ujváry, L Hanuš - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabidiol (CBD), the main nonpsychoactive constituent of Cannabis sativa, has shown a
wide range of therapeutically promising pharmacological effects either as a sole drug or in …

Human laboratory studies on cannabinoids and psychosis

M Sherif, R Radhakrishnan, DC D'Souza… - Biological …, 2016 - Elsevier
Some of the most compelling evidence supporting an association between cannabinoid
agonists and psychosis comes from controlled laboratory studies in humans. Randomized …

Oral cannabidiol does not alter the subjective, reinforcing or cardiovascular effects of smoked cannabis

M Haney, RJ Malcolm, S Babalonis, PA Nuzzo… - …, 2016 - nature.com
Cannabidiol (CBD), a constituent of cannabis with few psychoactive effects, has been
reported in some studies to attenuate certain aspects of Δ 9-tetrahydrocannabinol (THC) …

Cannabidiol as a potential new type of an antipsychotic. A critical review of the evidence

C Rohleder, JK Müller, B Lange… - Frontiers in …, 2016 - frontiersin.org
There is urgent need for the development of mechanistically different and less side-effect
prone antipsychotic compounds. The endocannabinoid system has been suggested to …

Brain imaging studies on the cognitive, pharmacological and neurobiological effects of cannabis in humans: evidence from studies of adult users

A Weinstein, A Livny, A Weizman - Current pharmaceutical …, 2016 - ingentaconnect.com
Cannabis is the most widely used illicit drug worldwide. Regular cannabis use has been
associated with a range of acute and chronic mental health problems, such as anxiety …

Cannabidiol regulation of learned fear: implications for treating anxiety-related disorders

R Jurkus, HLL Day, FS Guimarães, JLC Lee… - Frontiers in …, 2016 - frontiersin.org
Anxiety and trauma-related disorders are psychiatric diseases with a lifetime prevalence of
up to 25%. Phobias and post-traumatic stress disorder (PTSD) are characterized by …

Does cannabis cause, exacerbate or ameliorate psychiatric disorders? An oversimplified debate discussed

M Haney, AE Evins - Neuropsychopharmacology, 2016 - nature.com
There have been extensive policy shifts in the legality of recreational and therapeutic use of
cannabis in the United States, as well as a steady increase in the number of people using …

Bidirectional effects of cannabidiol on contextual fear memory extinction

C Song, CW Stevenson, FS Guimaraes… - Frontiers in …, 2016 - frontiersin.org
Cannabidiol (CBD) has been established to have both acute and long-lasting effects to
reduce fear memory expression. The long-lasting impact might be mediated by an …

Marijuana compounds: a nonconventional approach to Parkinson's disease therapy

M Babayeva, H Assefa, P Basu, S Chumki… - Parkinson's …, 2016 - Wiley Online Library
Parkinson's disease (PD), a neurodegenerative disorder, is the second most common
neurological illness in United States. Neurologically, it is characterized by the selective …

Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids

E Appiah-Kusi, E Leyden, S Parmar… - Psychological …, 2016 - cambridge.org
The aim of this article is to summarize current evidence regarding alterations in the
neuroendocrine stress response system and endocannabinoid system and their relationship …