The inability of cancer cells in taking care of DNA damages can lead to cancer development
and/or progression. Due to the essential role of DNA repair in maintaining genomic stability …

As a result of various stresses, lesions caused by DNA-damaging agents occur constantly in
each cell of the human body. Generally, DNA damage is recognized and repaired by the …

Pancreatic cancer, one of the most lethal human malignancies with dismal prognosis, is
refractory to existing radio-chemotherapeutic treatment modalities. There is a critical unmet …

Malignant mesothelioma (MM) is characterized by poor responsiveness to current
chemotherapeutic drugs, usually owing to high resistance to apoptosis. Here, we …

Background Exposure to particulate matter (PM) is associated with various health effects.
Physico-chemical properties influence the toxicological impact of PM, nonetheless the …

Oral cancer is an aggressive disease with the propensity for local recurrence and distal
metastasis in the head and neck region. Currently, cisplatin-based chemotherapy or …

DNA damage response and repair (DDR) is a tightly controlled process that serves as a
barrier to tumorigenesis. Consequently, DDR is frequently altered in human malignancy …

Nonmelanoma skin cancer (NMSC) is the most common cancer worldwide and the
incidence continues to rise, in part due to increasing numbers in high-risk groups such as …

Poly (ADP‐ribose) polymerase (PARP) inhibitors have proven to be successful agents in
inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached …

Cancer cells are commonly in a state of redox imbalance that drives their growth and
survival. To compensate for oxidative stress induced by the tumor redox environment …