Autophagy is a lysosome-dependent mechanism of intracellular degradation. The cellular
and molecular mechanisms underlying this process are highly complex and involve multiple …

Objectives To review the pathophysiology, co-morbidities, and therapeutic options for
psoriasis, psoriatic arthritis and rheumatoid arthritis in order to further understand the …

Aims The objective of this meta‐analysis was to determine whether gestational use of
hydroxychloroquine (HCQ) for autoimmune disorders leads to an increase in the risk for …

Rheumatoid arthritis (RA) is an autoimmune disease hallmarked by aberrant cellular
homeostasis, resulting in hyperactive CD4+ T cells that are more resistant to apoptosis. Both …

From the arrival of Chikungunya virus in the Americas in 2013 until March 2016,
approximately two million cases of the disease have been reported. In Brazil, the virus was …

In the antiretroviral therapy (ART) era, serious non-AIDS events (SNAEs) have become the
major causes of morbidity and mortality in HIV-infected persons. Early ART initiation has the …

Antibiotics (antibacterial, antiviral, and antiparasitic) are class of drugs which result in either
killing or inhibiting growth and multiplication of infectious organisms. Antibiotics are …

In endometriosis, the increased survival potential of shed endometrial cells (which normally
undergo anoikis) is suggested to promote lesion development. One mechanism that may …

Background Neuroblastoma (NB) is a frequent pediatric tumor characterized by a poor
prognosis where a majority of tumors progress despite intensive multimodality treatments …

Abstract Development of novel drugs for treatment of chronic inflammatory diseases is to a
large extent dependent on the availability of good experimental in vivo models in order to …