The new (dis) order in RNA regulation
AI Järvelin, M Noerenberg, I Davis… - Cell Communication and …, 2016 - Springer
RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …
Dysregulation of mRNA localization and translation in genetic disease
RNA-binding proteins (RBPs) acting at various steps in the post-transcriptional regulation of
gene expression play crucial roles in neuronal development and synaptic plasticity. Genetic …
gene expression play crucial roles in neuronal development and synaptic plasticity. Genetic …
[HTML][HTML] TRIBE: hijacking an RNA-editing enzyme to identify cell-specific targets of RNA-binding proteins
RNA transcripts are bound and regulated by RNA-binding proteins (RBPs). Current methods
for identifying in vivo targets of an RBP are imperfect and not amenable to examining small …
for identifying in vivo targets of an RBP are imperfect and not amenable to examining small …
Dynamic mRNA transport and local translation in radial glial progenitors of the developing brain
In the developing brain, neurons are produced from neural stem cells termed radial glia [1,
2]. Radial glial progenitors span the neuroepithelium, extending long basal processes to …
2]. Radial glial progenitors span the neuroepithelium, extending long basal processes to …
catRAPID signature: identification of ribonucleoproteins and RNA-binding regions
Motivation: Recent technological advances revealed that an unexpected large number of
proteins interact with transcripts even if the RNA-binding domains are not annotated. We …
proteins interact with transcripts even if the RNA-binding domains are not annotated. We …
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons
Fragile X syndrome (FXS) is caused by the absence of the Fragile X Mental Retardation
Protein (FMRP) in neurons. In the mouse, the lack of FMRP is associated with an excessive …
Protein (FMRP) in neurons. In the mouse, the lack of FMRP is associated with an excessive …
Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated …
RAM Buijsen, JA Visser, P Kramer… - Human …, 2016 - academic.oup.com
STUDY QUESTION Does repeat-associated non-AUG (RAN) translation play a role in fragile
X-associated primary ovarian insufficiency (FXPOI), leading to the presence of polyglycine …
X-associated primary ovarian insufficiency (FXPOI), leading to the presence of polyglycine …
Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model
C Cheng, SKM Lau, LC Doering - Molecular Brain, 2016 - Springer
Astrocytes are key participants in various aspects of brain development and function, many
of which are executed via secreted proteins. Defects in astrocyte signaling are implicated in …
of which are executed via secreted proteins. Defects in astrocyte signaling are implicated in …
FMRP expression levels in mouse central nervous system neurons determine behavioral phenotype
Fragile X mental retardation protein (FMRP) is absent or highly reduced in Fragile X
Syndrome, a genetic disorder causing cognitive impairment and autistic behaviors. Previous …
Syndrome, a genetic disorder causing cognitive impairment and autistic behaviors. Previous …