Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
R Rappuoli, MJ Bottomley, U D'Oro, O Finco… - Journal of Experimental …, 2016 - rupress.org
Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …
[HTML][HTML] Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G
Summary The HIV-1-envelope (Env) trimer is covered by a glycan shield of∼ 90 N-linked
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …
oligosaccharides, which comprises roughly half its mass and is a key component of HIV …
[HTML][HTML] Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth
Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best
available examples of the humoral immune response to HIV are providing important …
available examples of the humoral immune response to HIV are providing important …
[HTML][HTML] Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody
The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the
Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report …
Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report …
[HTML][HTML] Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses
Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a
universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza …
universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza …
[HTML][HTML] HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies
Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope
(Env) trimer are the most common bnAbs induced during infection, making them promising …
(Env) trimer are the most common bnAbs induced during infection, making them promising …
[HTML][HTML] Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies
Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine
development. VRC01-class bnAbs are important vaccine leads because their precursor B …
development. VRC01-class bnAbs are important vaccine leads because their precursor B …