Opportunities and challenges of big data for the social sciences: The case of genomic data

H Liu, G Guo - Social science research, 2016 - Elsevier
In this paper, we draw attention to one unique and valuable source of big data, genomic
data, by demonstrating the opportunities they provide to social scientists. We discuss …

Changing Polygenic Penetrance on Phenotypes in the 20th Century Among Adults in the US Population

D Conley, TM Laidley, JD Boardman, BW Domingue - Scientific reports, 2016 - nature.com
This study evaluates changes in genetic penetrance—defined as the association between
an additive polygenic score and its associated phenotype—across birth cohorts. Situating …

Multiple genetic associations with Irish wolfhound dilated cardiomyopathy

S Simpson, MD Dunning, S Brownlie… - BioMed research …, 2016 - Wiley Online Library
Cardiac disease is a leading cause of morbidity and mortality in dogs and humans, with
dilated cardiomyopathy being a large contributor to this. The Irish Wolfhound (IWH) is one of …

[PDF][PDF] The bell curve revisited: Testing controversial hypotheses with molecular genetic data

D Conley, B Domingue - Sociological Science, 2016 - sociologicalscience.com
In 1994, the publication of Herrnstein's and Murray's The Bell Curve resulted in a social
science maelstrom of responses. In the present study, we argue that Herrnstein's and …

Gendering genetics: Biological contingencies in the protective effects of social integration for men and women

BL Perry - American journal of sociology, 2016 - journals.uchicago.edu
Evidence that social and biological processes are intertwined in producing health and
human behavior is rapidly accumulating. Using a feminist approach, this research explores …

A genetic risk score is associated with polycystic ovary syndrome-related traits

H Lee, JY Oh, YA Sung, HW Chung - Human Reproduction, 2016 - academic.oup.com
STUDY QUESTION Is a genetic risk score (GRS) associated with polycystic ovary syndrome
(PCOS) and its related clinical features? SUMMARY ANSWER The GRS calculated by …

Weighted genetic risk scores and prediction of weight gain in solid organ transplant populations

N Saigi-Morgui, L Quteineh, PY Bochud, S Crettol… - PLoS …, 2016 - journals.plos.org
Background Polygenic obesity in Solid Organ Transplant (SOT) populations is considered a
risk factor for the development of metabolic abnormalities and graft survival. Few studies to …

Genome-wide estimates of heritability for social demographic outcomes

BW Domingue, R Wedow, D Conley… - … and Social Biology, 2016 - Taylor & Francis
An increasing number of studies that are widely used in the demographic research
community have collected genome-wide data from their respondents. It is therefore …

Smart homes and sensors for surveillance and preventive education at home: Example of obesity

J Demongeot, A Elena, M Jelassi, S Ben Miled… - Information, 2016 - mdpi.com
(1) Background: The aim of this paper is to show that e-health tools like smart homes allow
the personalization of the surveillance and preventive education of chronic patients, such as …

Association of genetic risk scores with body mass index in Swiss psychiatric cohorts

N Saigi-Morgui, F Vandenberghe… - Pharmacogenetics …, 2016 - journals.lww.com
Objective Weight gain is associated with psychiatric disorders and/or with psychotropic drug
treatments. We analyzed in three psychiatric cohorts under psychotropic treatment the …