Ankylosing spondylitis (AS), an immune-mediated arthritis, is the prototypic member of a
group of conditions known as spondyloarthropathies that also includes reactive arthritis …

Mechanistic target of rapamycin (mTOR, also known as mammalian target of rapamycin) is a
ubiquitous serine/threonine kinase that regulates cell growth, proliferation and survival …

The inflammatory diseases that are most strongly associated with major histocompatibility
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …

Intestinal barrier function, deletional tolerance, Th17 signature response, and endoplasmic
reticulum stress pathways have been recently linked to SpA. Dysregulated immune …

Objective To determine the influence of endoplasmic reticulum aminopeptidase 2 (ERAP‐2)
expression on the HLA–B* 27 peptidome in live cells. Methods Using immunoaffinity …

Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It
occurs both in isolation and as a complication of ankylosing spondylitis (AS). It is strongly …

Ankylosing spondylitis (AS) is a common chronic immune-mediated arthropathy affecting
primarily the spine and pelvis. The condition is strongly associated with HLA-B* 27 as well …

Psoriatic arthritis (PsA) is a chronic inflammatory disorder that belongs to the group of
spondyloarthritis (SpA). It was found that single nucleotide polymorphisms (SNPs) of …

Abstract Juvenile-onset spondyloarthritis (SpA), also known as enthesitis-related arthritis, is
a category of juvenile arthritis related to adult-onset SpA including several clinical forms. As …

Οι αμινοπεπτιδάσες ERAP1, ERAP2 και IRAP αποτελούν σημαντικά συστατικά του επίκτητου
ανοσοποιητικού συστήματος του ανθρώπου, συμμετέχοντας ενεργά στους μηχανισμούς …