Recognition of DNA and RNA by endosomal and cytosolic sensors constitutes a central
element in the detection of microbial invaders by the innate immune system. However, the …

Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …

Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated
inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair …

Type I interferon is a potent substance. As such, the induction, transmission, and resolution
of the type I interferon–mediated immune response are tightly regulated. As defined, the type …

Even small variations in dNTP concentrations decrease DNA replication fidelity, and this
observation prompted us to analyze genomic cancer data for mutations in enzymes involved …

SAMHD1 is a restriction factor for HIV-1 infection. SAMHD1 mutations cause the
autoinflammatory Aicardi-Goutières syndrome that is characterized by chronic type I …

Defects of the intracellular enzyme 3′ repair exonuclease 1 (Trex1) cause the rare
autoimmune condition Aicardi–Goutières syndrome and are associated with systemic lupus …

SAMHD1 is a cellular dNTPase that restricts lentiviral infection presumably by lowering
cellular dNTP levels to below a critical threshold required for reverse transcription; however …

A large proportion of the human genome consists of endogenous retroviruses, some of
which are well preserved, showing transcriptional activity, and expressing retroviral proteins …

IFN-ε is a unique type I IFN that is not induced by pattern recognition response elements. IFN-
ε is constitutively expressed in mucosal tissues, including the female genital mucosa …