There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials
are so far largely unsuccessful as a preventive or curative measure. Chronic low‐grade …

Human body is continuously exposed to different types of agents that results in the
production of reactive species called as free radicals (ROS/RNS) which by the transfer of …

Inflammation is a biological defense mechanism caused by the interruption of the tissue
homeostasis caused by the presence of a biological, chemical, or physical agents in the …

There is widespread recognition that reactive oxygen species (ROS) play key roles in
normal brain function and pathology in the context of neurological disease. Oxidative stress …

A popular belief is that reactive oxygen species (ROS) and reactive nitrogen species (RNS)
produced during exercise by the mitochondria and other subcellular compartments …

The presence of reactive oxygen species (ROS) in living organisms was described more
than 60 years ago and virtually immediately it was suggested that ROS were involved in …

Abstract Anthracyclines, eg, doxorubicin (DOX), and anthracenediones, eg, mitoxantrone
(MTX), are drugs used in the chemotherapy of several cancer types, including solid and non …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …