Immune responses demonstrate a high level of intra-species variation, compensating for the
specialization capacity of pathogens. The recent advent of in-depth immune phenotyping …

Human cytomegalovirus (HCMV) is a ubiquitous β-herpes virus that has co-evolved with its
host since the very beginning of human life. The vast majority of adults worldwide carry the …

The impact of epigenetics on the differentiation of memory T (Tmem) cells is poorly defined.
We generated deep epigenomes comprising genome-wide profiles of DNA methylation …

A latent infection with cytomegalovirus (CMV), a ubiquitous beta herpesvirus, is associated
with an accumulation of late-differentiated memory T-cells, often accompanied by a …

Purpose There are well-known alterations occurring within the immune system with aging.
Collectively, these changes are known as immunosenescence. The incidence of …

The elderly population is more susceptible to infections as a result of an altered immune
response, commonly referred to as immunosenescence. Cytomegalovirus (CMV)-infection …

Background Psychosocial stress is thought to play a key role in the acceleration of
immunological aging. This study investigated the relationship between lifetime and past …

Autoreactivity may play a critical role in the chronification of atopic dermatitis (AD). Several
studies showed that AD patients produce IgE Abs specific for autoantigens, and we …

According to the current paradigm, the main cause of AD is the accumulation of neurotoxic
amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor …

Abstract Background. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) induce effector
memory T-cell expansions, which are variable and potentially depend on the age at primary …