Epigenetic mechanisms of longevity and aging
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …
From ancient pathways to aging cells—connecting metabolism and cellular senescence
CD Wiley, J Campisi - Cell metabolism, 2016 - cell.com
Cellular senescence is a complex stress response that permanently arrests the proliferation
of cells at risk for oncogenic transformation. However, senescent cells can also drive …
of cells at risk for oncogenic transformation. However, senescent cells can also drive …
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Cellular senescence, a stress-induced irreversible growth arrest often characterized by
expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …
expression of p16Ink4a (encoded by the Ink4a/Arf locus, also known as Cdkn2a) and a …
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
While reports suggest a single dose of senolytics may improve vasomotor function, the
structural and functional impact of long‐term senolytic treatment is unknown. To determine …
structural and functional impact of long‐term senolytic treatment is unknown. To determine …
Senescence of T lymphocytes: implications for enhancing human immunity
As humans live longer, a central concern is to find ways to maintain their health as they age.
Immunity declines during ageing, as shown by the increased susceptibility to infection by …
Immunity declines during ageing, as shown by the increased susceptibility to infection by …
Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
B Bakker, A Taudt, ME Belderbos, D Porubsky… - Genome biology, 2016 - Springer
Background Chromosome instability leads to aneuploidy, a state in which cells have
abnormal numbers of chromosomes, and is found in two out of three cancers. In a …
abnormal numbers of chromosomes, and is found in two out of three cancers. In a …
Vascular cell senescence contributes to blood–brain barrier breakdown
Background and Purpose—Age-related changes in the cerebrovasculature, including blood–
brain barrier (BBB) disruption, are emerging as potential risks for diverse neurological …
brain barrier (BBB) disruption, are emerging as potential risks for diverse neurological …
Living in CIN: mitotic infidelity and its consequences for tumor promotion and suppression
LC Funk, LM Zasadil, BA Weaver - Developmental cell, 2016 - cell.com
Errors in chromosome segregation during mitosis have been recognized as a hallmark of
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …
tumor cells since the late 1800s, resulting in the long-standing hypothesis that mitotic …
Cellular senescence as the causal nexus of aging
N Bhatia-Dey, RR Kanherkar, SE Stair… - Frontiers in …, 2016 - frontiersin.org
In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …
Regenerative decline of stem cells in sarcopenia
P Sousa-Victor, P Muñoz-Cánoves - Molecular aspects of medicine, 2016 - Elsevier
Skeletal muscle mass and function decline with aging, a process known as sarcopenia,
which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is …
which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is …