Epidemiological studies and mouse models suggest that maternal immune activation,
induced clinically through prenatal exposure to one of several infectious diseases, is a risk …

Celiac disease (CeD) is a complex immune-mediated disease. Genetic studies have
implicated 43 predisposing loci that collectively explain some 50% of the genetic variance in …

The physiological functions of natural killer (NK) cells in human immunity and reproduction
depend upon diverse interactions between killer cell immunoglobulin-like receptors (KIRs) …

Abstract IPD-IMGT/HLA is a constituent of the Immuno Polymorphism Database (IPD), which
was developed to provide a centralised system for the study of polymorphism in genes of the …

Genetic risk for autoimmunity in HLA genes is most often attributed to structural specificity
resulting in presentation of self-antigens. Autoimmune vitiligo is strongly associated with the …

Background Alzheimer's disease (AD) is the most common form of dementia in older adults
that damages the brain and results in impaired memory, thinking and behaviour. The …

Rationale: Sarcoidosis is a multisystem disease of unknown cause. Löfgren's syndrome (LS)
is a characteristic subgroup of sarcoidosis that is associated with a good prognosis in …

Background The ability to capture and sequence large contiguous DNA fragments
represents a significant advancement towards the comprehensive characterization of …

Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem
cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood …

Deleterious mutations are expected to evolve under negative selection and are usually
purged from the population. However, deleterious alleles segregate in the human …