Incretins

T Wu, CK Rayner, M Horowitz - Metabolic control, 2016 - Springer
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
are the known incretin hormones in humans, released predominantly from the …

Incretin-based therapies for diabetic complications: basic mechanisms and clinical evidence

D Kawanami, K Matoba, K Sango… - International Journal of …, 2016 - mdpi.com
An increase in the rates of morbidity and mortality associated with diabetic complications is a
global concern. Glycemic control is important to prevent the development and progression of …

99mTc Labeled Glucagon-Like Peptide-1-Analogue (99mTc-GLP1) Scintigraphy in the Management of Patients with Occult Insulinoma

A Sowa-Staszczak, M Trofimiuk-Müldner, A Stefańska… - PloS one, 2016 - journals.plos.org
Introduction The aim of this study was to assess the utility of [Lys40 (Ahx-HYNIC-
99mTc/EDDA) NH2]-exendin-4 scintigraphy in the management of patients with …

Positioning SGLT2 inhibitors/incretin-based therapies in the treatment algorithm

JPH Wilding, SP Rajeev, RA DeFronzo - Diabetes Care, 2016 - Am Diabetes Assoc
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are the most recent addition to the
therapeutic options available for the treatment of type 2 diabetes and became available after …

Changes in insulin sensitivity and secretion after sleeve gastrectomy

G Casella, E Soricelli… - Journal of British …, 2016 - academic.oup.com
Background Sleeve gastrectomy is indicated for the treatment of obesity and related co-
morbidity including diabetes. The dynamic changes in insulin secretion and sensitivity after …

The value of short-and long-acting glucagon-like peptide-1 agonists in the management of type 2 diabetes mellitus: experience with exenatide

XH Guo - Current Medical Research and Opinion, 2016 - Taylor & Francis
Background: Only about half of patients with type 2 diabetes treated with antihyperglycemic
drugs achieve glycemic control (HbA1c< 7%), most commonly due to poor treatment …

Efficacy and acceptability of glycemic control of glucagon-like peptide-1 receptor agonists among type 2 diabetes: a systematic review and network meta-analysis

Z Li, Y Zhang, X Quan, Z Yang, X Zeng, L Ji, F Sun… - PLoS …, 2016 - journals.plos.org
Objective To synthesize current evidence of the impact of Glucagon-like peptide-1 receptor
agonists (GLP-1 RAs) on hypoglycemia, treatment discontinuation and glycemic level in …

Effect of sitagliptin on blood glucose control in patients with type 2 diabetes mellitus who are treatment naive or poorly responsive to existing antidiabetic drugs: the …

H Sakura, N Hashimoto, K Sasamoto, H Ohashi… - BMC endocrine …, 2016 - Springer
Background To investigate the ameliorating effect of sitagliptin, a dipeptidyl peptidase-4
inhibitor, on blood glucose control in patients with type 2 diabetes mellitus who were …

Pharmacological actions of glucagon-like peptide-1, gastric inhibitory polypeptide, and glucagon

R Sekar, K Singh, AWR Arokiaraj, BKC Chow - International review of cell …, 2016 - Elsevier
Glucagon family of peptide hormones is a group of structurally related brain-gut peptides
that exert their pleiotropic actions through interactions with unique members of class B1 G …

Tumour risk with once-weekly glucagon-like peptide-1 receptor agonists in type 2 diabetes mellitus patients: a systematic review

X Guo, Q Yang, J Dong, L Liao, W Zhang… - Clinical drug …, 2016 - Springer
Abstract Background and Objective Once-weekly glucagon-like peptide-1 receptor agonists
(GLP-1RAs) are a novel class of injectable antidiabetic drugs. Previous studies indicated …