Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors
and currently effective treatment options are still lacking. GBM is frequently accompanied …

To develop effective disease-modifying therapies for neurodegenerative diseases, reliable
markers of diagnosis, disease activity and progression are a research priority. The fact that …

Purpose To evaluate the association of multiparametric and multiregional magnetic
resonance (MR) imaging features with key molecular characteristics in patients with newly …

Since the beginning of the last decade, exosomes have been of increased interest in the
science community. Exosomes represent a new kind of long distance transfer of biological …

Intratumoral heterogeneity of signaling networks may contribute to targeted cancer therapy
resistance, including in the highly lethal brain cancer glioblastoma (GBM). We performed …

In addition to each of the factors that govern the identification of a successful oncology drug
candidate, drug discovery aimed at treating neurological cancer must also consider the …

Reactive oxygen species (ROS) represent reactive products belonging to the partial
reduction of oxygen. It has been reported that ROS are involved in different signaling …

Opinion statement High-grade gliomas remain incurable despite current therapies, which
are plagued by high morbidity and mortality. Molecular categorization of glioma subtypes …

Assays that can determine the response of tumor cells to cancer therapeutics could greatly
aid the selection of drug regimens for individual patients. However, the utility of current …

Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor
is generally worse than methylated MGMT tumors, as temozolomide (TMZ) response is …