The Perseus computational platform for comprehensive analysis of (prote) omics data
A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis …
quantitative protein abundance data generated using mass-spectrometry-based analysis …
[HTML][HTML] Design and computational analysis of single-cell RNA-sequencing experiments
R Bacher, C Kendziorski - Genome biology, 2016 - Springer
Single-cell RNA-sequencing (scRNA-seq) has emerged as a revolutionary tool that allows
us to address scientific questions that eluded examination just a few years ago. With the …
us to address scientific questions that eluded examination just a few years ago. With the …
Network analysis of depression and anxiety symptom relationships in a psychiatric sample
BackgroundResearchers have studied psychological disorders extensively from a common
cause perspective, in which symptoms are treated as independent indicators of an …
cause perspective, in which symptoms are treated as independent indicators of an …
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …
contributions are profoundly heterogeneous but may converge on common pathways that …
[PDF][PDF] Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …
Chromosome conformation elucidates regulatory relationships in developing human brain
Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
[PDF][PDF] Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation
H Lui, J Zhang, SR Makinson, MK Cahill, KW Kelley… - Cell, 2016 - cell.com
Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
What are'good'depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis
Abstract Background The symptoms for Major Depression (MD) defined in the DSM-5 differ
markedly from symptoms assessed in common rating scales, and the empirical question …
markedly from symptoms assessed in common rating scales, and the empirical question …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons
MS Cembrowski, L Wang, K Sugino, BC Shields… - elife, 2016 - elifesciences.org
Clarifying gene expression in narrowly defined neuronal populations can provide insight
into cellular identity, computation, and functionality. Here, we used next-generation RNA …
into cellular identity, computation, and functionality. Here, we used next-generation RNA …