An update on inflamm‐aging: mechanisms, prevention, and treatment

S Xia, X Zhang, S Zheng, R Khanabdali… - Journal of …, 2016 - Wiley Online Library
Inflamm‐aging is a challenging and promising new branch of aging‐related research fields
that includes areas such as immunosenescence. Increasing evidence indicates that inflamm …

[HTML][HTML] The microbiome: a key regulator of stress and neuroinflammation

K Rea, TG Dinan, JF Cryan - Neurobiology of stress, 2016 - Elsevier
There is a growing emphasis on the relationship between the complexity and diversity of the
microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease …

Inflammaging and anti-inflammaging: the role of cytokines in extreme longevity

PL Minciullo, A Catalano, G Mandraffino… - Archivum immunologiae …, 2016 - Springer
Longevity and aging are two sides of the same coin, as they both derive from the interaction
between genetic and environmental factors. Aging is a complex, dynamic biological process …

Effects of ageing on the immune system: infants to elderly

R Valiathan, M Ashman… - Scandinavian journal of …, 2016 - Wiley Online Library
Physiological ageing is accompanied by decline in immune system function and immune
alteration during ageing increases susceptibility to infections. We retrospectively analysed …

[HTML][HTML] Aging of mice is associated with p16 (Ink4a)-and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

BM Hall, V Balan, AS Gleiberman, E Strom… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …

Inflammaging decreases adaptive and innate immune responses in mice and humans

D Frasca, BB Blomberg - Biogerontology, 2016 - Springer
Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

Chronic peripheral inflammation, hippocampal neurogenesis, and behavior

V Chesnokova, RN Pechnick, K Wawrowsky - Brain, behavior, and …, 2016 - Elsevier
Adult hippocampal neurogenesis is involved in memory and learning, and disrupted
neurogenesis is implicated in cognitive impairment and mood disorders, including anxiety …

Matrix ageing and vascular impacts: focus on elastin fragmentation

L Duca, S Blaise, B Romier, M Laffargue… - Cardiovascular …, 2016 - academic.oup.com
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

Effect of a prebiotic formulation on frailty syndrome: a randomized, double-blind clinical trial

C Buigues, J Fernández-Garrido, L Pruimboom… - International journal of …, 2016 - mdpi.com
Aging can result in major changes in the composition and metabolic activities of bacterial
populations in the gastrointestinal system and result in impaired function of the immune …

BMI and BMD: the potential interplay between obesity and bone fragility

A Palermo, D Tuccinardi, G Defeudis… - International journal of …, 2016 - mdpi.com
Recent evidence demonstrating an increased fracture risk among obese individuals
suggests that adipose tissue may negatively impact bone health, challenging the traditional …