Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

A Zhernakova, A Kurilshikov, MJ Bonder, EF Tigchelaar… - Science, 2016 - science.org
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-
based cohort shows relations between the microbiome and 126 exogenous and intrinsic …

Chronic administration of catestatin improves autonomic function and exerts cardioprotective effects in myocardial infarction rats

D Wang, T Liu, S Shi, R Li, Y Shan… - Journal of …, 2016 - journals.sagepub.com
Catestatin (CST), which is emerging as a novel cardiac modulator, can protect the heart
against excessive sympathetic drive in hypertensive cardiomyopathy. The aim of this study is …

Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo

T Pasqua, S Mahata, GK Bandyopadhyay… - Cell and tissue …, 2016 - Springer
Chromogranin A (CgA) is a prohormone and granulogenic factor in neuroendocrine tissues
with a regulated secretory pathway. The impact of CgA depletion on secretory granule …

Identification of prohormones and pituitary neuropeptides in the African cichlid, Astatotilapia burtoni

CK Hu, BR Southey, EV Romanova, KP Maruska… - BMC genomics, 2016 - Springer
Background Cichlid fishes have evolved remarkably diverse reproductive, social, and
feeding behaviors. Cell-to-cell signaling molecules, notably neuropeptides and peptide …

Prognostic value of secretoneurin in critically ill patients with infections

H Røsjø, M Stridsberg, AH Ottesen, S Nygård… - Critical care …, 2016 - journals.lww.com
Objectives: Secretoneurin is produced in neuroendocrine cells, and the myocardium and
circulating secretoneurin levels provide incremental prognostic information to established …

Excitatory and inhibitory neurons in the hippocampus exhibit molecularly distinct large dense core vesicles

JJ Ramírez-Franco, FJ Munoz-Cuevas… - Frontiers in cellular …, 2016 - frontiersin.org
Hippocampal interneurons comprise a diverse family of inhibitory neurons that are critical for
detailed information processing. Along with gamma-aminobutyric acid (GABA), interneurons …

[HTML][HTML] Regulation of tumor growth by circulating full-length chromogranin A

F Curnis, A Dallatomasina, M Bianco, A Gasparri… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Chromogranin A (CgA), a neuroendocrine secretory protein, and its fragments are present in
variable amounts in the blood of normal subjects and cancer patients. We investigated …

Prognostic value of secretoneurin in patients with acute respiratory failure: data from the FINNALI Study

PL Myhre, AH Ottesen, M Okkonen, R Linko… - Clinical …, 2016 - academic.oup.com
BACKGROUND We examined whether secretoneurin (SN), a biomarker associated with
cardiomyocyte Ca2+ handling, provides prognostic information in patients with acute …

Carboxypeptidase E and secretogranin III coordinately facilitate efficient sorting of proopiomelanocortin to the regulated secretory pathway in AtT20 cells

NX Cawley, T Rathod, S Young, H Lou… - Molecular …, 2016 - academic.oup.com
Proopiomelanocortin (POMC) is a multivalent prohormone that can be processed into at
least 7 biologically active peptide hormones. Processing can begin in the trans-Golgi …

Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus)

M Mikwar, L Navarro-Martin, L Xing, H Volkoff, W Hu… - Peptides, 2016 - Elsevier
Secretoneurin (SN) is a conserved peptide derived by proteolytic processing from the middle
domain of the∼ 600 amino acid precursor secretogranin-II (SgII). Secretoneurin is widely …