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Ankylosing spondylitis (AS), an immune-mediated arthritis, is the prototypic member of a
group of conditions known as spondyloarthropathies that also includes reactive arthritis …

Enthesitis is a central feature of spondyloarthritis (SpA). Although enthesitis has traditionally
been considered to be a focal insertional disorder, advanced imaging and pathologic …

The inflammatory diseases that are most strongly associated with major histocompatibility
Complex class I (MHC-I) alleles are also influenced by endoplasmic reticulum …

CD8+ T cells are key players in the body's defence against viral infections and cancer. To
date, data on the role of CD8+ T cells in autoimmune diseases have been scarce, especially …

Despite the progress in human leukocyte antigen (HLA) causal variant mapping,
independent localization of major histocompatibility complex (MHC) risk from classical HLA …

Intestinal barrier function, deletional tolerance, Th17 signature response, and endoplasmic
reticulum stress pathways have been recently linked to SpA. Dysregulated immune …

Acute anterior uveitis (AAU) involves inflammation of the iris and ciliary body of the eye. It
occurs both in isolation and as a complication of ankylosing spondylitis (AS). It is strongly …

Objective Dissimilarities in antigen processing and presentation are known to contribute to
the differential association of HLA–B* 27 subtypes with the inflammatory rheumatic disease …

Abstract Endoplasmic reticulum aminopeptidase 1 (ERAP1) is involved in the final
processing of peptide precursors to generate the N-termini of MHC class I-restricted …