The Perseus computational platform for comprehensive analysis of (prote) omics data
A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis …
quantitative protein abundance data generated using mass-spectrometry-based analysis …
Network biology concepts in complex disease comorbidities
The co-occurrence of diseases can inform the underlying network biology of shared and
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …
multifunctional genes and pathways. In addition, comorbidities help to elucidate the effects …
Personalized characterization of diseases using sample-specific networks
A complex disease generally results not from malfunction of individual molecules but from
dysfunction of the relevant system or network, which dynamically changes with time and …
dysfunction of the relevant system or network, which dynamically changes with time and …
Inferring causal molecular networks: empirical assessment through a community-based effort
It remains unclear whether causal, rather than merely correlational, relationships in
molecular networks can be inferred in complex biological settings. Here we describe the …
molecular networks can be inferred in complex biological settings. Here we describe the …
[HTML][HTML] The antitumor effects of geraniol: Modulation of cancer hallmark pathways
M Cho, I So, JN Chun, JH Jeon - … journal of oncology, 2016 - spandidos-publications.com
Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic
plants. To date, experimental evidence supports the therapeutic or preventive effects of …
plants. To date, experimental evidence supports the therapeutic or preventive effects of …
DyNet: visualization and analysis of dynamic molecular interaction networks
The ability to experimentally determine molecular interactions on an almost proteome-wide
scale under different conditions is enabling researchers to move from static to dynamic …
scale under different conditions is enabling researchers to move from static to dynamic …
Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states
To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we
developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity …
developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity …
The Next Generation of Risk Assessment multi-year study—highlights of findings, applications to risk assessment, and future directions
I Cote, ME Andersen, GT Ankley… - Environmental …, 2016 - ehp.niehs.nih.gov
Background: The Next Generation (NexGen) of Risk Assessment effort is a multi-year
collaboration among several organizations evaluating new, potentially more efficient …
collaboration among several organizations evaluating new, potentially more efficient …
Network-based approaches for analysis of complex biological systems
Cells function and respond to changes in their environment by the coordinated activity of
their molecular components, including mRNAs, proteins and metabolites. At the heart of …
their molecular components, including mRNAs, proteins and metabolites. At the heart of …
[PDF][PDF] Translation of genotype to phenotype by a hierarchy of cell subsystems
Accurately translating genotype to phenotype requires accounting for the functional impact
of genetic variation at many biological scales. Here, we present a strategy for genotype …
of genetic variation at many biological scales. Here, we present a strategy for genotype …